DCK

Gene Information

Official Symbol: DCK
Official Name: deoxycytidine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 1633
UniProt: P27707
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008].
UniProt Summary: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. {ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:20614893}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aphidicolin 0.4μM R08 exp440	-2.91
CI-1040 9.5μM R08 exp472	-2.07
IL-3 9ng/ml R08 exp493	-1.84
Nicotinate 1000μM R03 exp140	1.72
Lapatinib 5μM R01 exp47	1.73
Methotrexate 0.01μM R08 exp501	1.77
BI-6727 0.001μM R01 exp42	1.8
5-Azacytidine 2μM R07 exp330	2.19
FBS-Wisent 0.1 R07 exp426	6.45

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17833
Expression level (log2 read counts): 6.09

Expression Distribution

deoxycytidine kinase activity
deoxynucleoside kinase activity
deoxyribonucleoside monophosphate biosynthetic process
pyrimidine-containing compound salvage
pyrimidine nucleoside salvage
deoxyribonucleoside monophosphate metabolic process
purine-containing compound salvage
pyrimidine nucleoside biosynthetic process
nucleoside salvage
cellular metabolic compound salvage
pyrimidine nucleoside metabolic process
nucleoside biosynthetic process
glycosyl compound biosynthetic process
nucleoside monophosphate biosynthetic process
pyrimidine-containing compound biosynthetic process
drug binding
pyrimidine nucleotide metabolic process
nucleoside monophosphate metabolic process
nucleobase-containing small molecule biosynthetic process
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
purine-containing compound biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
carbohydrate derivative biosynthetic process
protein homodimerization activity
organophosphate metabolic process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
phosphorylation
organic cyclic compound biosynthetic process