DNAJC10
Gene Information
- Official Symbol: DNAJC10
- Official Name: DnaJ heat shock protein family (Hsp40) member C10
- Aliases and Previous Symbols: N/A
- Entrez ID: 54431
- UniProt: Q8IXB1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Thioredoxin |
| DnaJ |
GO Terms
| oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
| disulfide oxidoreductase activity |
| endoplasmic reticulum chaperone complex |
| protein folding in endoplasmic reticulum |
| protein disulfide oxidoreductase activity |
| ATPase activator activity |
| misfolded protein binding |
| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| Hsp70 protein binding |
| positive regulation of ATPase activity |
| ubiquitin-dependent ERAD pathway |
| cell redox homeostasis |
| ATPase binding |
| regulation of ATPase activity |
| ERAD pathway |
| chaperone binding |
| intrinsic apoptotic signaling pathway |
| protein folding |
| response to endoplasmic reticulum stress |
| apoptotic signaling pathway |
| endoplasmic reticulum lumen |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| proteolysis involved in cellular protein catabolic process |
| negative regulation of protein modification process |
| cellular protein catabolic process |
| protein catabolic process |
| positive regulation of hydrolase activity |
| cellular homeostasis |
| cellular macromolecule catabolic process |
| apoptotic process |
| oxidation-reduction process |
| response to organonitrogen compound |
| endoplasmic reticulum |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| cell death |
| negative regulation of protein metabolic process |
| proteolysis |
| regulation of hydrolase activity |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| homeostatic process |
| intracellular signal transduction |
| cellular response to stress |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of protein modification process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13356
- Expression level (log2 read counts): 7.83
Expression Distribution
DNAJC10 Expression in NALM6 Cells: 7.83
