DOT1L

Gene Information
  • Official Symbol: DOT1L
  • Official Name: DOT1 like histone lysine methyltransferase
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 84444
  • UniProt: Q8TEK3
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011].
  • UniProt Summary: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 2468
  • Expression level (log2 read counts): 7.33

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1