DRC1

• Official Symbol: DRC1
• Official Name: dynein regulatory complex subunit 1
• Aliases and Previous Symbols: N/A
• Entrez ID: 92749
• UniProt: Q96MC2
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a central component of the nexin-dynein complex (N-DRC), which regulates the assembly of ciliary dynein. Mutations in this gene can cause ciliary dyskinesia. [provided by RefSeq, Aug 2015].
• UniProt Summary: Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending. {ECO:0000269|PubMed:23354437}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 18416
• Expression level (log2 read counts): -4.6

Expression Distribution

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DRC1 Expression in NALM6 Cells: -4.6