DTX3

Entrez Summary: N/A
UniProt Summary: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SGC0946 7μM R03 exp151	-1.76
MS023 2μM R03 exp134	-1.7
Tozasertib 0.1μM R07 exp414	1.71
Docetaxel 0.002μM R01 exp45	1.72
Dexamethasone 0.006μM R07 exp351	1.8
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.84
Cincreasin 100μM R08 exp473	1.86
Epigallocatechin gallate 20μM R05 exp230	1.9
Cyclosporin-A 3μM R07 exp348	1.91
BRD2 inhibitor II 20μM R07 exp341	1.92
A-769662 20μM R07 exp331	2.24
GSK-J4 1μM R07 exp362	2.24

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

transferase activity
Notch signaling pathway
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal