DYNLL1
Gene Information
- Official Symbol: DYNLL1
- Official Name: dynein light chain LC8-type 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8655
- UniProt: P63167
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
Pfam Domains GO Terms
Pfam Domains
| Dynein light |
GO Terms
| positive regulation of ATP-dependent microtubule motor activity, plus-end-directed |
| regulation of ATP-dependent microtubule motor activity, plus-end-directed |
| positive regulation of microtubule motor activity |
| nitric-oxide synthase regulator activity |
| positive regulation of non-motile cilium assembly |
| regulation of microtubule motor activity |
| intraciliary retrograde transport |
| regulation of non-motile cilium assembly |
| cytoplasmic dynein complex |
| motile cilium assembly |
| positive regulation of cilium assembly |
| dynein complex |
| ATP-dependent microtubule motor activity, plus-end-directed |
| dynein intermediate chain binding |
| dynein light intermediate chain binding |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| COP9 signalosome |
| intraciliary transport involved in cilium assembly |
| substantia nigra development |
| ciliary tip |
| intraciliary transport |
| positive regulation of ATPase activity |
| axon cytoplasm |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| scaffold protein binding |
| ficolin-1-rich granule membrane |
| neural nucleus development |
| microtubule-based protein transport |
| protein transport along microtubule |
| positive regulation of insulin secretion |
| tertiary granule membrane |
| positive regulation of organelle assembly |
| mitotic spindle |
| regulation of cilium assembly |
| regulation of ATPase activity |
| midbrain development |
| kinetochore |
| ciliary basal body-plasma membrane docking |
| positive regulation of peptide hormone secretion |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| positive regulation of plasma membrane bounded cell projection assembly |
| positive regulation of hormone secretion |
| G2/M transition of mitotic cell cycle |
| cell cycle G2/M phase transition |
| spermatid development |
| transport along microtubule |
| spermatid differentiation |
| macroautophagy |
| organelle localization by membrane tethering |
| cytoskeleton-dependent intracellular transport |
| antigen processing and presentation of exogenous peptide antigen |
| regulation of insulin secretion |
| membrane docking |
| microtubule-based transport |
| antigen processing and presentation of exogenous antigen |
| protein C-terminus binding |
| antigen processing and presentation of peptide antigen |
| regulation of G2/M transition of mitotic cell cycle |
| cilium |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| regulation of peptide hormone secretion |
| regulation of cell cycle G2/M phase transition |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| antigen processing and presentation |
| regulation of organelle assembly |
| protein domain specific binding |
| protein-containing complex localization |
| germ cell development |
| autophagy |
| process utilizing autophagic mechanism |
| regulation of hormone secretion |
| mitotic cell cycle phase transition |
| positive regulation of protein secretion |
| microtubule-based movement |
| cell cycle phase transition |
| positive regulation of peptide secretion |
| microtubule |
| cilium assembly |
| enzyme binding |
| cellular process involved in reproduction in multicellular organism |
| cilium organization |
| Golgi vesicle transport |
| positive regulation of cell projection organization |
| positive regulation of secretion by cell |
| regulation of mitotic cell cycle phase transition |
| positive regulation of protein transport |
| positive regulation of secretion |
| negative regulation of phosphorylation |
| plasma membrane bounded cell projection assembly |
| regulation of cell cycle phase transition |
| cell projection assembly |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| neutrophil degranulation |
| protein heterodimerization activity |
| centrosome |
| neutrophil activation involved in immune response |
| regulation of peptide secretion |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| positive regulation of cellular component biogenesis |
| myeloid cell activation involved in immune response |
| regulation of hormone levels |
| spermatogenesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| male gamete generation |
| organelle localization |
| myeloid leukocyte activation |
| mitotic cell cycle process |
| positive regulation of organelle organization |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of mitotic cell cycle |
| developmental process involved in reproduction |
| microtubule-based process |
| mitotic cell cycle |
| gamete generation |
| regulation of plasma membrane bounded cell projection organization |
| viral process |
| regulated exocytosis |
| regulation of protein transport |
| regulation of cell projection organization |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of cell cycle process |
| organelle assembly |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| head development |
| symbiotic process |
| exocytosis |
| regulation of secretion |
| interspecies interaction between organisms |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| protein homodimerization activity |
| regulation of cellular localization |
| apoptotic process |
| leukocyte activation |
| regulation of cellular component biogenesis |
| central nervous system development |
| positive regulation of transport |
| multi-organism reproductive process |
| intracellular protein transport |
| cell cycle process |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| programmed cell death |
| cell activation |
| immune effector process |
| cell death |
| plasma membrane bounded cell projection organization |
| secretion |
| cell projection organization |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| mitochondrion |
| regulation of hydrolase activity |
| regulation of organelle organization |
| cell cycle |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| protein transport |
| intracellular transport |
| peptide transport |
| movement of cell or subcellular component |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| cell development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ATMIN | 0.683 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 29/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 2/28 |
| bone | 1/25 |
| breast | 1/33 |
| central nervous system | 4/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 2/15 |
| kidney | 2/21 |
| liver | 2/20 |
| lung | 5/75 |
| lymphocyte | 0/14 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3656
- Expression level (log2 read counts): 6.76
Expression Distribution
DYNLL1 Expression in NALM6 Cells: 6.76
