EIF2S1

Gene Information

Official Symbol: EIF2S1
Official Name: eukaryotic translation initiation factor 2 subunit alpha
Aliases and Previous Symbols: N/A
Entrez ID: 1965
UniProt: P05198
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2- GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0125461 0.74μM R02 exp84	-2.84
Tanespimycin 14μM R08 exp527	-2.47
ML-792 0.2μM R08 exp505	-1.94
LY2090314 0.003μM R08 exp499	-1.77
CyclicAMP 200μM R08 exp475	1.71
Vincristine 0.0005μM R04 exp190	1.86
ETC-159 50μM R08 exp480	1.89
Actinomycin-D 0.001μM R00 exp3	1.92
Rapamycin 0.001μM R08 exp429	1.99
Ibrutinib 10μM R08 exp442	2.32
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	2.43
Hydroxychloroquine 30μM R08 exp490	2.52
Oligomycin-A 2μM R00 exp25	2.54
Hippuristanol 0.12μM R08 exp488	2.81
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	2.85

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 292
Expression level (log2 read counts): 7.05

Expression Distribution

Gene	Correlation
MCRS1	0.422
MYC	0.409

EIF 2 alpha
S1

translation initiation ternary complex
multi-eIF complex
positive regulation of type B pancreatic cell apoptotic process
response to manganese-induced endoplasmic reticulum stress
glial limiting end-foot
negative regulation of translational initiation in response to stress
negative regulation of guanyl-nucleotide exchange factor activity
eukaryotic translation initiation factor 2 complex
eukaryotic translation initiation factor 2B complex
negative regulation of translation in response to stress
regulation of guanyl-nucleotide exchange factor activity
regulation of type B pancreatic cell apoptotic process
regulation of translational initiation in response to stress
cellular response to manganese ion
PERK-mediated unfolded protein response
regulation of GTP binding
eukaryotic 48S preinitiation complex
regulation of translation in response to stress
stress granule assembly
negative regulation of translational initiation
response to manganese ion
positive regulation of epithelial cell apoptotic process
ER-nucleus signaling pathway
cellular response to amino acid starvation
polysome
response to amino acid starvation
translation initiation factor activity
ribosome binding
cytoplasmic stress granule
cellular response to heat
regulation of translational initiation
regulation of epithelial cell apoptotic process
cellular response to UV
positive regulation of neuron death
negative regulation of protein binding
endoplasmic reticulum unfolded protein response
response to heat
cellular response to light stimulus
cellular response to unfolded protein
negative regulation of translation