EIF4E2

Entrez Summary: N/A
UniProt Summary: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). {ECO:0000250|UniProtKB:Q8BMB3, ECO:0000269|PubMed:17368478, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:9582349}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.0125μM R03 exp97	-3
BI-2536 0.0042μM R03 exp95	-2.7
Colchicine 0.009μM R05 exp215	-2.48
GSK461364A 0.005μM R03 exp125	-2.21
Erlotinib 10μM R05 exp216	-2.15
ML-792 0.2μM R08 exp505	-2.05
SGC0946 7μM R03 exp151	-2.02
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.99
MS023 2μM R03 exp134	-1.96
Olaparib 4μM R08 exp512	-1.94
Resveratrol 16μM R03 exp147	-1.94
Aphidicolin 0.4μM R08 exp440	-1.82
Azithromycin 100μM R08 exp452	-1.8
Etoposide 0.1μM R05 exp198	-1.78
UM0129480 7μM R02 exp85	-1.78
NFN1 1μM R03 exp100	-1.75
QNZ 0.01μM R05 exp241	2
I-BRD9 4μM R07 exp365	2.84

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA cap binding
mRNA cap binding complex
RNA 7-methylguanosine cap binding
eukaryotic translation initiation factor 4F complex
translation factor activity, RNA binding
translation initiation factor activity
negative regulation of translation
translational initiation
negative regulation of cellular amide metabolic process
ubiquitin protein ligase binding
regulation of translation
in utero embryonic development
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
chordate embryonic development
embryo development ending in birth or egg hatching
cellular amide metabolic process
embryo development
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of cellular macromolecule biosynthetic process
RNA binding
organonitrogen compound biosynthetic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
negative regulation of gene expression
macromolecule biosynthetic process
gene expression