ELF1

Entrez Summary: N/A
UniProt Summary: Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-2.42
Bleomycin 5μM R08 exp459	-1.9
Docetaxel 0.002μM R01 exp45	-1.7
MS023 2μM R03 exp134	1.76
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.86
AICAR 240μM R03 exp116	1.87
Benzoate 10000μM R08 exp455	1.89
TRAIL 5ng/ml R00 exp35	1.89
VER-155008 3.9μM R06 exp301	1.93
Erlotinib 10μM R05 exp216	1.99
Dimethyl-Sulfoxide 1pc R03 exp120	2.09
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	2.23
Oligomycin-A 2μM R00 exp25	2.27
Betulinic acid 10 to 15μM on day4 R05 exp222	2.49
RK-33 8μM R08 exp518	2.65
Tunicamycin 0.04μM R07 exp418	2.8
Vemurafenib 6.6μM R02 exp89	2.92
I-BRD9 4μM R07 exp365	3.02
Q15 2.7μM R02 exp79	3.03
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	3.08
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	3.09
TRAIL 50ng/ml R00 exp36	3.1
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	3.25
Vemurafenib 6.6μM R08 exp434	4.46

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ets
Elf-1 N

negative regulation of T cell receptor signaling pathway
regulation of B cell receptor signaling pathway
negative regulation of antigen receptor-mediated signaling pathway
regulation of T cell receptor signaling pathway
regulation of antigen receptor-mediated signaling pathway
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
negative regulation of immune system process
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
DNA-binding transcription factor activity
regulation of cytokine production
regulation of immune response
positive regulation of transcription by RNA polymerase II
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of response to stimulus
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of immune system process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process