FBXL20

Gene Information

Official Symbol: FBXL20
Official Name: F-box and leucine rich repeat protein 20
Aliases and Previous Symbols: N/A
Entrez ID: 84961
UniProt: Q96IG2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MS023 7μM R03 exp135	1.7
Trimetrexate 0.03μM R08 exp535	1.7
THZ531 0.11μM R07 exp409	1.71
Taxol 0.004μM R03 exp103	1.8
Bortezomib 0.005μM R00 exp6	1.81
Mdivi-1 15μM R05 exp217	1.81
Arsenate 40μM R06 exp264	1.86
Menadione 5μM R06 exp292	1.93
Cycloheximide 0.02μM R00 exp14	1.95
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.98
Rotenone 20μM R00 exp34	1.99
VER-155008 3.9μM R06 exp301	2
iCRT14 30μM R08 exp492	2.04
Vemurafenib 6.6μM R08 exp434	2.04
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.1
Demecolcine 0.03μM R05 exp228	2.16
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.17
GSK626616 14μM R08 exp485	2.25
Thimerosal 0.85μM R08 exp529	2.25
Bortezomib 0.05μM R00 exp7	2.54
Actinomycin-D 0.001μM R00 exp3	2.82
MS023 2μM R03 exp134	2.89
THZ531 0.11 to 0.175μM on day4 R07 exp413	3.07
THZ531 0.225μM R08 exp444	3.67

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14307
Expression level (log2 read counts): 5.36

Expression Distribution

F-box
F-box-like

regulation of protein catabolic process at presynapse, modulating synaptic transmission
presynaptic modulation of chemical synaptic transmission
behavioral fear response
behavioral defense response
fear response
SCF ubiquitin ligase complex
multicellular organismal response to stress
regulation of synaptic vesicle exocytosis
Schaffer collateral - CA1 synapse
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
presynapse
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
regulation of neurotransmitter transport
regulation of regulated secretory pathway
regulation of exocytosis
ubiquitin-protein transferase activity
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
glutamatergic synapse
proteasomal protein catabolic process
regulation of neurotransmitter levels
post-translational protein modification
regulation of protein catabolic process
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
regulation of vesicle-mediated transport
behavior
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
regulation of secretion by cell
protein modification by small protein conjugation
regulation of secretion
cellular macromolecule catabolic process
regulation of cellular localization