GPATCH1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.23
RS-1 10μM R08 exp519	-2.22
Radicicol 0.16μM R05 exp242	-2.04
Resminostat 0.5μM R07 exp393	-1.99
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.84
Prochlorperazine 5.2μM R02 exp77	1.74
Lapatinib 5μM R01 exp47	1.78
WNT3A 44ng/ml R08 exp537	1.8
DKK1 89ng/ml R08 exp477	1.86

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF1604
G-patch

catalytic step 2 spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
mRNA metabolic process
RNA processing
RNA binding
RNA metabolic process
gene expression