GTF2F2

Gene Information

Official Symbol: GTF2F2
Official Name: general transcription factor IIF subunit 2
Aliases and Previous Symbols: N/A
Entrez ID: 2963
UniProt: P13984
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA- helicase activity. {ECO:0000269|PubMed:2477704}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK591 2.6μM R03 exp128	-2.4
CHIR-124 0.04μM R06 exp272	-2.02
FK-506 30μM R07 exp359	-2.01
Cidofovir 10μM R07 exp345	-1.99
RO-3307 4.7μM R02 exp80	-1.9
All-trans-Retinoic-Acid 8μM R07 exp333	-1.86
LB-100 4.1μM R02 exp72	-1.82
THZ1 0.06μM R08 exp531	1.71

Global Fraction of Cell Lines Where Essential: 95/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	2/28
blood	4/28
bone	2/25
breast	4/33
central nervous system	9/56
cervix	1/4
colorectal	2/17
esophagus	1/13
fibroblast	0/1
gastric	1/15
kidney	2/21
liver	3/20
lung	14/75
lymphocyte	3/14
ovary	1/26
pancreas	2/24
peripheral nervous system	1/16
plasma cell	3/15
prostate	0/1
skin	5/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	5/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1969
Expression level (log2 read counts): 5.39

Expression Distribution

transcription factor TFIIF complex
transcriptional preinitiation complex
positive regulation of transcription elongation from RNA polymerase II promoter
regulation of transcription elongation from RNA polymerase II promoter
positive regulation of DNA-templated transcription, elongation
7-methylguanosine mRNA capping
7-methylguanosine RNA capping
RNA capping
positive regulation of viral transcription
regulation of DNA-templated transcription, elongation
DNA helicase activity
regulation of viral transcription
snRNA transcription by RNA polymerase II
snRNA transcription
transcription elongation from RNA polymerase II promoter
fibroblast growth factor receptor signaling pathway
DNA-templated transcription, elongation
ncRNA transcription
positive regulation of viral process
cellular response to fibroblast growth factor stimulus
DNA duplex unwinding
response to fibroblast growth factor
DNA geometric change
microtubule cytoskeleton
transcription initiation from RNA polymerase II promoter
regulation of viral process
DNA-templated transcription, initiation
regulation of symbiosis, encompassing mutualism through parasitism
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
DNA conformation change
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
transcription by RNA polymerase II
cellular response to growth factor stimulus
positive regulation of multi-organism process
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
transcription, DNA-templated