H2AFV

Entrez Summary: N/A
UniProt Summary: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Latrunculin-B 10μM R07 exp374	-2.32
Cyclosporin-A 0.8μM R07 exp347	-2.09
Cycloheximide 0.02μM R00 exp14	-2.03
Metformin 100 to 150μM on day4 R04 exp170	-1.93
Apcin 25μM plus proTAME 2μM R04 exp177	-1.89
Rifampicin 1μM R00 exp31	-1.82
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.8
MLN-4924 2μM R00 exp22	-1.77
CyclicAMP 200μM R08 exp475	-1.72
JQ1 0.8μM R08 exp435	1.74
Etoposide 0.1μM R05 exp198	1.82
Vinblastine 0.015μM R05 exp208	2.02
AICAR 240μM R05 exp211	2.3
SB743921 0.001μM R05 exp244	2.32

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nucleosome
nuclear chromatin
protein heterodimerization activity
chromatin organization
molecular function
chromosome organization
DNA binding