HGS

Gene Information

Official Symbol: HGS
Official Name: hepatocyte growth factor-regulated tyrosine kinase substrate
Aliases and Previous Symbols: N/A
Entrez ID: 9146
UniProt: O14964
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.59
Cannabidiol 20μM R08 exp466	-2.16
Rotenone 2μM R00 exp33	-2.03
Dorsomorphin 5μM R07 exp357	-1.99
SGC2096 2.6μM R03 exp153	-1.98
CCT251545 20μM R07 exp326	-1.97
L-74142 5μM R03 exp131	-1.91
BI-2536 0.0042μM R03 exp95	-1.87
Aminopterin 0.005μM R07 exp335	-1.86
Hydroxyurea 100μM R07 exp329	-1.81
Diepoxybutane 3μM R07 exp354	-1.8
Cyclosporin-A 0.8μM R07 exp347	-1.79
Vemurafenib 6.6μM R08 exp434	-1.79
UNC1999 2μM R03 exp155	-1.74
LJH685 5μM R02 exp73	-1.72

Global Fraction of Cell Lines Where Essential: 62/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	7/28
bone	2/26
breast	6/33
central nervous system	4/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	3/16
kidney	1/21
liver	2/20
lung	5/75
lymphocyte	3/16
ovary	4/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1913
Expression level (log2 read counts): 6.29

Expression Distribution

VHS
Hrs helical
FYVE

ESCRT-0 complex
multivesicular body membrane
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of exosomal secretion
regulation of exosomal secretion
negative regulation of receptor signaling pathway via JAK-STAT
protein targeting to lysosome
negative regulation of receptor signaling pathway via STAT
ubiquitin-like protein ligase binding
regulation of platelet-derived growth factor receptor signaling pathway
multivesicular body assembly
multivesicular body organization
regulation of vascular endothelial growth factor receptor signaling pathway
protein targeting to vacuole
protein localization to lysosome
negative regulation of epidermal growth factor receptor signaling pathway
establishment of protein localization to vacuole
negative regulation of ERBB signaling pathway
protein localization to vacuole
endosome organization
regulation of epidermal growth factor receptor signaling pathway
positive regulation of exocytosis
regulation of ERBB signaling pathway
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
lysosomal transport
negative regulation of vasculature development
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
vacuolar transport
membrane invagination
negative regulation of cellular response to growth factor stimulus
early endosome membrane
macroautophagy
regulation of exocytosis
endosomal transport
protein domain specific binding
lysosome
early endosome