ITSN2

Entrez Summary: This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017].
UniProt Summary: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	-2.19
Vemurafenib 6.6μM R08 exp434	-1.87
UM0011500 5μM R05 exp245	-1.79
YM155 0.001μM R08 exp432	-1.76
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.73
Docetaxel 0.002μM R01 exp45	-1.7
LLY-283 2.6μM R06 exp290	1.79
Disulfiram 4.3μM R06 exp281	1.8
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.84
Chlorpromazine 10μM R07 exp344	2.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of dendrite extension
regulation of dendrite extension
SH3/SH2 adaptor activity
Rho guanyl-nucleotide exchange factor activity
regulation of Rho protein signal transduction
positive regulation of cell growth
positive regulation of developmental growth
regulation of Ras protein signal transduction
positive regulation of growth
positive regulation of neuron projection development
regulation of developmental growth
regulation of small GTPase mediated signal transduction
positive regulation of neuron differentiation
positive regulation of cell projection organization
regulation of cell growth
positive regulation of neurogenesis
regulation of cell morphogenesis
centrosome
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
endocytosis
regulation of neuron differentiation
regulation of growth
import into cell
regulation of plasma membrane bounded cell projection organization
viral process
regulation of cell projection organization
calcium ion binding
symbiotic process
regulation of neurogenesis
interspecies interaction between organisms
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
regulation of anatomical structure morphogenesis
positive regulation of cellular component organization
positive regulation of developmental process
generation of neurons
neurogenesis