JARID2

Gene Information

Official Symbol: JARID2
Official Name: jumonji and AT-rich interaction domain containing 2
Aliases and Previous Symbols: N/A
Entrez ID: 3720
UniProt: Q92833
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. {ECO:0000269|PubMed:20075857}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Menadione 5μM R06 exp292	-2.04
BN82002 4μM R07 exp340	-1.73
5-Azacytidine 2μM R07 exp330	-1.71
2-Deoxy-D-glucose 800μM R05 exp214	1.77
UM0131023 0.05μM R05 exp248	1.79
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.25

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12633
Expression level (log2 read counts): 6.09

Expression Distribution

JmjN
zf-C5HC2
JmjC
ARID

histone demethylase activity (H3-trimethyl-K4 specific)
histone H3-K4 demethylation, trimethyl-H3-K4-specific
histone H3-K4 demethylation
positive regulation of histone H3-K9 methylation
negative regulation of cardiac muscle cell proliferation
histone demethylase activity
ESC/E(Z) complex
negative regulation of histone methylation
regulation of histone H3-K9 methylation
negative regulation of heart growth
negative regulation of cardiac muscle tissue growth
negative regulation of cardiac muscle hypertrophy
histone lysine demethylation
negative regulation of muscle hypertrophy
histone demethylation
protein demethylation
protein dealkylation
negative regulation of organ growth
negative regulation of cardiac muscle tissue development
spleen development
positive regulation of histone methylation
regulation of cardiac muscle cell proliferation
negative regulation of histone modification
histone methyltransferase complex
thymus development
negative regulation of striated muscle tissue development
negative regulation of muscle organ development
negative regulation of muscle tissue development
regulation of cardiac muscle hypertrophy
regulation of cardiac muscle tissue growth
regulation of muscle hypertrophy
negative regulation of chromatin organization
regulation of heart growth
demethylation
regulation of histone methylation
regulation of cardiac muscle tissue development
negative regulation of gene expression, epigenetic
regulation of muscle adaptation
positive regulation of histone modification
regulation of organ growth