LYL1

Entrez Summary: This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	-2.97
Rapamycin 10μM R00 exp30	-2.08
Etoposide 0.1μM R05 exp198	-1.98
Rapamycin 1μM R00 exp29	-1.96
Pomalidomide 20μM R07 exp391	-1.94
Lead acetate 2000μM R08 exp498 no dilution day6	-1.86
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.84
Bortezomib 0.005μM R00 exp6	-1.76
UM0011500 10μM R05 exp246	1.72
Hippuristanol 0.12μM R08 exp488	1.94

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

blood vessel maturation
definitive hemopoiesis
B cell differentiation
anatomical structure maturation
B cell activation
protein dimerization activity
lymphocyte differentiation
developmental maturation
RNA polymerase II regulatory region sequence-specific DNA binding
leukocyte differentiation
lymphocyte activation
blood vessel development
vasculature development
cardiovascular system development
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
circulatory system development
leukocyte activation
cell activation
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process