MAP3K12
Gene Information
- Official Symbol: MAP3K12
- Official Name: mitogen-activated protein kinase kinase kinase 12
- Aliases and Previous Symbols: N/A
- Entrez ID: 7786
- UniProt: Q12852
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
GO Terms
| negative regulation of motor neuron apoptotic process |
| regulation of motor neuron apoptotic process |
| JUN kinase kinase kinase activity |
| activation of JNKK activity |
| histone phosphorylation |
| activation of JUN kinase activity |
| activation of MAPKK activity |
| positive regulation of JUN kinase activity |
| JNK cascade |
| peptidyl-threonine phosphorylation |
| regulation of JUN kinase activity |
| peptidyl-threonine modification |
| stress-activated MAPK cascade |
| growth cone |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| negative regulation of neuron apoptotic process |
| activation of MAPK activity |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| peptidyl-serine phosphorylation |
| regulation of JNK cascade |
| protein autophosphorylation |
| peptidyl-serine modification |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| protein kinase activity |
| positive regulation of MAP kinase activity |
| regulation of ERK1 and ERK2 cascade |
| regulation of neuron death |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| protein serine/threonine kinase activity |
| histone modification |
| MAPK cascade |
| covalent chromatin modification |
| signal transduction by protein phosphorylation |
| protein kinase binding |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| chromatin organization |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of kinase activity |
| protein homodimerization activity |
| peptidyl-amino acid modification |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| protein phosphorylation |
| regulation of transferase activity |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| chromosome organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5034
- Expression level (log2 read counts): 4.42
Expression Distribution
MAP3K12 Expression in NALM6 Cells: 4.42
