MAP3K7
Gene Information
- Official Symbol: MAP3K7
- Official Name: mitogen-activated protein kinase kinase kinase 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 6885
- UniProt: O43318
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
GO Terms
| IkappaB kinase complex |
| anoikis |
| I-kappaB phosphorylation |
| Ada2/Gcn5/Ada3 transcription activator complex |
| activation of NF-kappaB-inducing kinase activity |
| positive regulation of T cell cytokine production |
| MAP kinase kinase kinase activity |
| nucleotide-binding oligomerization domain containing signaling pathway |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
| positive regulation of interleukin-2 production |
| regulation of T cell cytokine production |
| MyD88-dependent toll-like receptor signaling pathway |
| cytoplasmic pattern recognition receptor signaling pathway |
| Wnt signaling pathway, calcium modulating pathway |
| histone H3 acetylation |
| positive regulation of T cell mediated immunity |
| activation of MAPKK activity |
| regulation of interleukin-2 production |
| positive regulation of cytokine production involved in immune response |
| receptor tyrosine kinase binding |
| scaffold protein binding |
| positive regulation of macroautophagy |
| I-kappaB kinase/NF-kappaB signaling |
| regulation of T cell mediated immunity |
| positive regulation of JUN kinase activity |
| positive regulation of NIK/NF-kappaB signaling |
| NIK/NF-kappaB signaling |
| JNK cascade |
| regulation of cytokine production involved in immune response |
| regulation of JUN kinase activity |
| interleukin-1-mediated signaling pathway |
| positive regulation of production of molecular mediator of immune response |
| toll-like receptor signaling pathway |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| transforming growth factor beta receptor signaling pathway |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| stress-activated MAPK cascade |
| regulation of NIK/NF-kappaB signaling |
| stimulatory C-type lectin receptor signaling pathway |
| histone acetylation |
| innate immune response activating cell surface receptor signaling pathway |
| internal peptidyl-lysine acetylation |
| positive regulation of autophagy |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| pattern recognition receptor signaling pathway |
| positive regulation of leukocyte mediated immunity |
| non-canonical Wnt signaling pathway |
| positive regulation of JNK cascade |
| regulation of production of molecular mediator of immune response |
| stress-activated protein kinase signaling cascade |
| protein acetylation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of lymphocyte mediated immunity |
| positive regulation of NF-kappaB transcription factor activity |
| activation of MAPK activity |
| cellular response to transforming growth factor beta stimulus |
| regulation of adaptive immune response |
| response to transforming growth factor beta |
| intracellular receptor signaling pathway |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| regulation of macroautophagy |
| Fc-epsilon receptor signaling pathway |
| cellular response to interleukin-1 |
| T cell receptor signaling pathway |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of JNK cascade |
| protein acylation |
| response to interleukin-1 |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of leukocyte mediated immunity |
| endosome membrane |
| magnesium ion binding |
| positive regulation of immune effector process |
| innate immune response-activating signal transduction |
| regulation of stress-activated MAPK cascade |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of stress-activated protein kinase signaling cascade |
| protein kinase activity |
| Fc receptor signaling pathway |
| activation of innate immune response |
| positive regulation of MAP kinase activity |
| positive regulation of DNA-binding transcription factor activity |
| protein deubiquitination |
| antigen receptor-mediated signaling pathway |
| protein modification by small protein removal |
| peptidyl-lysine modification |
| activation of protein kinase activity |
| regulation of autophagy |
| positive regulation of protein serine/threonine kinase activity |
| positive regulation of innate immune response |
| regulation of MAP kinase activity |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| positive regulation of response to biotic stimulus |
| protein serine/threonine kinase activity |
| histone modification |
| positive regulation of cellular catabolic process |
| MAPK cascade |
| covalent chromatin modification |
| signal transduction by protein phosphorylation |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of DNA-binding transcription factor activity |
| positive regulation of catabolic process |
| positive regulation of cytokine production |
| immune response-activating cell surface receptor signaling pathway |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| cellular response to growth factor stimulus |
| positive regulation of multi-organism process |
| regulation of protein serine/threonine kinase activity |
| regulation of response to biotic stimulus |
| response to growth factor |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| immune response-activating signal transduction |
| positive regulation of kinase activity |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| activation of immune response |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| chromatin organization |
| viral process |
| enzyme linked receptor protein signaling pathway |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of multi-organism process |
| symbiotic process |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| positive regulation of immune response |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| apoptotic process |
| protein phosphorylation |
| regulation of transferase activity |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| positive regulation of phosphorylation |
| chromosome organization |
| identical protein binding |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| proteolysis |
| phosphorylation |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| ATP binding |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 2/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5071
- Expression level (log2 read counts): 6.2
Expression Distribution
MAP3K7 Expression in NALM6 Cells: 6.2
