MAT2B

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L- methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R01 exp48	-1.81
Bafilomycin-A1 0.009μM R08 exp454	1.7
LLY-284 2.6μM R06 exp291	1.75
Dynasore 7μM R08 exp436	1.77
LJH685 5μM R02 exp73	1.78
Hinokiflavone 12μM R08 exp487	1.87
Fluvastatin 2.2μM R06 exp282	1.9
Chloroquine 32μM R08 exp470	2.02
Hydroxyurea 100μM R07 exp329	2.12
Deferoxamine 11μM R07 exp350	2.44
MS023 7μM R03 exp135	2.54
Hydroxychloroquine 30μM R08 exp490	2.6
MS023 2μM R03 exp134	2.76
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.77
Cryptotanshinone 12μM R05 exp227	3.47
ABT-702 5μM plus CoCl2 18μM R07 exp320	3.63
CoCl2 18μM R07 exp346	4.11

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

methionine adenosyltransferase regulator activity
methionine adenosyltransferase complex
S-adenosylmethionine biosynthetic process
S-adenosylmethionine metabolic process
one-carbon metabolic process
coenzyme biosynthetic process
sulfur compound biosynthetic process
cofactor biosynthetic process
coenzyme metabolic process
methylation
enzyme binding
sulfur compound metabolic process
cofactor metabolic process
drug metabolic process
small molecule metabolic process