MNT

Gene Information

Official Symbol: MNT
Official Name: MAX network transcriptional repressor
Aliases and Previous Symbols: N/A
Entrez ID: 4335
UniProt: Q99583
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
iCRT14 30μM R08 exp492	-2.51
Trientine 500μM R08 exp534	-2.11
AICAR 240μM R03 exp116	-2.02
Bortezomib 0.05μM R00 exp7	-1.79
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.74
HMS-I2 5μM R06 exp287	1.74
3-Bromopyruvate 7μM R04 exp175	1.76
Vinorelbine 0.001μM R05 exp249	1.76
TRAIL 5ng/ml R00 exp35	2.17
Rifampicin 1μM R00 exp31	2.19
TRAIL 50ng/ml R00 exp36	3.33

Global Fraction of Cell Lines Where Essential: 2/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 904
Expression level (log2 read counts): 5.7

Expression Distribution

Gene	Correlation
BCL2L1	0.521
SAMD4B	0.469

cell aging
protein dimerization activity
negative regulation of apoptotic signaling pathway
transcription corepressor activity
DNA-binding transcription repressor activity, RNA polymerase II-specific
aging
transcription coactivator activity
RNA polymerase II regulatory region sequence-specific DNA binding
chromatin binding
regulation of apoptotic signaling pathway
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
negative regulation of cell population proliferation
negative regulation of transcription by RNA polymerase II
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
regulation of apoptotic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death