MRPS36

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phenformin 20μM R05 exp212	-1.87
proTAME 5μM R04 exp187	-1.85
RS-1 10μM R08 exp519	-1.73
Geldanamycin 0.01μM R05 exp235	-1.7
Calcium Ionophore 0.4μM R07 exp342	1.77
Temozolomide 200μM R04 exp189	1.88
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.91
UM0125461 0.74μM R02 exp84	1.91
SNS-032 25μM R07 exp401	1.94
Dorsomorphin 5μM R07 exp357	2.05
AICAR 240μM R03 exp116	2.43
Hydroxyurea 100μM R07 exp329	2.48

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial oxoglutarate dehydrogenase complex
oxoglutarate dehydrogenase (succinyl-transferring) activity
2-oxoglutarate metabolic process
mitochondrial small ribosomal subunit
mitochondrial translational termination
mitochondrial translational elongation
dicarboxylic acid metabolic process
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
cofactor metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression