MSL3

Entrez Summary: This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010].
UniProt Summary: May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. {ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22547026}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Talazoparib 0.006μM R06 exp299	-2.28
Olaparib 4μM R08 exp512	-2.26
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.08
Sulforaphane 9μM R08 exp525	-1.97
Thimerosal 0.85μM R08 exp529	-1.97
Dynasore 7μM R08 exp436	-1.91
Staurosporine 0.02μM R08 exp524	-1.91
Clomiphene 4.4μM R02 exp68	-1.85
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.83
5-Azacytidine 2μM R07 exp330	-1.81
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.8
Epothilone-B 0.0015μM R05 exp231	-1.78
Tubacin 1.6μM R07 exp416	-1.76
UM0129480 7μM R02 exp85	-1.75
Aphidicolin 0.4μM R08 exp440	-1.74
Trimetrexate 0.03μM R08 exp535	-1.73

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

MRG
Tudor-knot

MSL complex
histone H2A acetylation
NuA4 histone acetyltransferase complex
histone H4-K16 acetylation
histone acetyltransferase complex
histone deacetylation
protein deacetylation
histone H4 acetylation
chromatin organization involved in negative regulation of transcription
chromatin silencing
methylated histone binding
protein deacylation
macromolecule deacylation
chromatin organization involved in regulation of transcription
negative regulation of gene expression, epigenetic
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
gene silencing
protein acylation
regulation of gene expression, epigenetic
peptidyl-lysine modification
histone modification
covalent chromatin modification
chromatin organization
peptidyl-amino acid modification
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression