NCOA5
Gene Information
- Official Symbol: NCOA5
- Official Name: nuclear receptor coactivator 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 57727
- UniProt: Q9HCD5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6518
- Expression level (log2 read counts): 6.01