NEDD1

Entrez Summary: N/A
UniProt Summary: Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.004μM R03 exp103	-2.82
Ammonium tetrathiomolybdate 10μM R08 exp448	-2.04
Artemisinin 50μM R08 exp450	-2
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.84
IU1-47 25μM R04 exp182	1.74
BI-6727 0.001μM R01 exp42	1.78
NFN1 1μM R03 exp100	1.78
Ethanol 0.003 R08 exp437	1.79
Alpha-Amanitin 0.5μM R00 exp5	2.01
JQ1 0.01μM R03 exp130	2.1
A-366 10μM R03 exp115	2.33

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

protein localization to microtubule organizing center
pericentriolar material
protein localization to centrosome
protein localization to microtubule cytoskeleton
protein localization to cytoskeleton
apical part of cell
ciliary basal body-plasma membrane docking
spindle pole
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
ciliary basal body
centriole
organelle localization by membrane tethering
membrane docking
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
mitotic cell cycle phase transition
cell cycle phase transition
cilium assembly
cilium organization
regulation of mitotic cell cycle phase transition
plasma membrane bounded cell projection assembly
regulation of cell cycle phase transition
cell projection assembly
centrosome
cell division
organelle localization
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
protein localization to organelle
regulation of cell cycle process
organelle assembly
cell cycle process
plasma membrane bounded cell projection organization
cell projection organization
regulation of cell cycle
cell cycle
cellular protein localization
cellular macromolecule localization