NFYA

Gene Information

Official Symbol: NFYA
Official Name: nuclear transcription factor Y subunit alpha
Aliases and Previous Symbols: N/A
Entrez ID: 4800
UniProt: P23511
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000269|PubMed:12741956}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Brefeldin A 0.02μM R00 exp8	-2.35
MLN-4924 2μM R00 exp22	-2.02
CVT-10216 0.1μM R06 exp278	-1.95
NFN1 1μM R03 exp100	1.71
Celastrol 0.12μM R05 exp225	1.83
RS-1 10μM R08 exp519	1.92
Tubacin 1.6μM R07 exp416	2.15
Dynasore 10μM R04 exp180	2.23

Gene	Correlation
RRM1	0.559
POLR2J3	0.53
TCEB3CL2	0.451
TCEB3C	0.433
TCEB3CL	0.429
MBTD1	0.425
TBC1D3F	0.424
PRIM1	0.419
SUPT5H	0.416
VPS28	0.408
PRPF19	0.406
TBC1D3H	0.403

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1302
Expression level (log2 read counts): 6.64

Expression Distribution

CCAAT-binding factor complex
regulation of sterol biosynthetic process
regulation of cholesterol biosynthetic process
protein-DNA complex
regulation of cholesterol metabolic process
RNA polymerase II transcription factor complex
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
RNA polymerase II distal enhancer sequence-specific DNA binding
regulation of steroid metabolic process
regulation of lipid biosynthetic process
transcription regulatory region DNA binding
rhythmic process
regulation of lipid metabolic process
regulation of small molecule metabolic process
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression