NUDT2

Entrez Summary: N/A
UniProt Summary: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.39
Hippuristanol 0.12μM R08 exp488	-2.26
Rapamycin 1μM R00 exp29	-1.97
Thapsigargin 0.005μM R07 exp407	-1.88
Chloramphenicol 2μM R00 exp12	-1.77
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.76
Ribavirin 10μM R01 exp52	2.39
CyclicAMP 200μM R08 exp475	2.74
Ribavirin 10 to 15μM on day4 R04 exp160	5.35
AICAR 240μM R03 exp116	8.48
AICAR 240μM R05 exp211	8.48

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

bis(5-nucleosyl)-tetraphosphatase (symmetrical) activity
bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity
cellular response to oxidative stress
mitochondrial matrix
response to oxidative stress
GTP binding
apoptotic process
programmed cell death
cell death
cellular response to stress