OAZ1

Gene Information

Official Symbol: OAZ1
Official Name: ornithine decarboxylase antizyme 1
Aliases and Previous Symbols: N/A
Entrez ID: 4946
UniProt: P54368
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147). {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:26305948, ECO:0000269|PubMed:26443277}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Azithromycin 100μM R08 exp452	1.7
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.7
Temozolomide 200μM R04 exp189	1.74
MK2206 4μM R08 exp504	1.75
IU1-C 25μM R04 exp183	1.85
ZLN024 50μM R08 exp538	1.85
Dimethyloxaloylglycine 100μM R05 exp229	2
VER-155008 3.9μM R06 exp301	2.09
Cannabidiol 20μM R08 exp466	2.22
MS023 7μM R03 exp135	2.37
Dorsomorphin 5μM R07 exp357	2.43
5-Fluorouracil 20μM R00 exp2	2.57

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1985
Expression level (log2 read counts): 8.49

Expression Distribution

negative regulation of polyamine transmembrane transport
ornithine decarboxylase inhibitor activity
regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
cellular biogenic amine biosynthetic process
amine biosynthetic process
cellular biogenic amine metabolic process
cellular amine metabolic process
regulation of cellular amino acid metabolic process
amine metabolic process
regulation of cellular amine metabolic process
negative regulation of transmembrane transport
positive regulation of intracellular protein transport
regulation of cellular ketone metabolic process
positive regulation of intracellular transport
positive regulation of protein catabolic process
regulation of intracellular protein transport
positive regulation of cellular protein localization
regulation of intracellular transport
regulation of protein catabolic process
positive regulation of protein transport
regulation of small molecule metabolic process
positive regulation of catabolic process
positive regulation of establishment of protein localization
negative regulation of transport
regulation of cellular protein localization
regulation of transmembrane transport
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
negative regulation of catalytic activity
regulation of cellular localization
positive regulation of transport
regulation of catabolic process
regulation of protein localization
negative regulation of molecular function
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
positive regulation of protein metabolic process