OPTN

Gene Information

Official Symbol: OPTN
Official Name: optineurin
Aliases and Previous Symbols: N/A
Entrez ID: 10133
UniProt: Q96CV9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ML-792 0.2μM R08 exp505	-2.16
Monensin 0.3μM R08 exp507	-2.15
Apcin 50 to 100μM on day4 R04 exp176	-2.03
Rucaparib 6.5μM R08 exp520	-2
TRAIL 5ng/ml R00 exp35	-1.96
Ibrutinib 10μM R08 exp442	-1.89
Pyrazinamide 100μM R08 exp516	-1.84
DKK1 89ng/ml R08 exp477	-1.81
SB203580 25μM R03 exp149	1.84
SGC2043 10μM R03 exp152	1.87
Nicotinamide Riboside 100μM R03 exp139	1.9
BI-2536 0.0042μM R03 exp95	1.96
UNC1999 2μM R03 exp155	2.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8115
Expression level (log2 read counts): 4.18

Expression Distribution

negative regulation of receptor recycling
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
regulation of xenophagy
positive regulation of xenophagy
positive regulation of mitophagy in response to mitochondrial depolarization
positive regulation of mitophagy
Golgi ribbon formation
positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
regulation of autophagy of mitochondrion in response to mitochondrial depolarization
regulation of mitophagy
positive regulation of autophagy of mitochondrion
response to mitochondrial depolarisation
K63-linked polyubiquitin modification-dependent protein binding
regulation of receptor recycling
protein localization to Golgi apparatus
polyubiquitin modification-dependent protein binding
Golgi to plasma membrane protein transport
regulation of autophagy of mitochondrion
negative regulation of I-kappaB kinase/NF-kappaB signaling
establishment of protein localization to plasma membrane
Golgi to plasma membrane transport
positive regulation of macroautophagy
autophagosome
protein binding, bridging
recycling endosome membrane
defense response to Gram-negative bacterium
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
positive regulation of mitochondrion organization
positive regulation of autophagy
cellular response to unfolded protein
G2/M transition of mitotic cell cycle
Golgi organization
cell cycle G2/M phase transition
cellular response to topologically incorrect protein
Rab GTPase binding
response to unfolded protein
trans-Golgi network
regulation of macroautophagy
regulation of mitochondrion organization