PNP

Entrez Summary: This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008].
UniProt Summary: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. {ECO:0000269|PubMed:2104852}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 5μM R03 exp102	-2.24
Hypoxia 5%O2 R04 exp191	-2.09
Mubritinib 0.2μM R02 exp65	-2.07
Deguelin 0.05μM R02 exp69	-1.7
FK-506 30μM R07 exp359	1.74
BI-2536 0.02μM R03 exp96	1.76
Epigallocatechin gallate 20μM R05 exp230	1.78
Apcin 50 to 100μM on day4 R04 exp176	1.93
Mitomycin-C 0.06μM R08 exp503	2.04

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

purine-nucleoside phosphorylase activity
inosine catabolic process
pyridine nucleoside catabolic process
pyridine nucleoside metabolic process
nicotinamide riboside metabolic process
nicotinamide riboside catabolic process
purine nucleobase binding
interleukin-2 secretion
urate biosynthetic process
inosine metabolic process
nucleoside binding
pyridine-containing compound catabolic process
interleukin-2 production
purine ribonucleoside catabolic process
purine nucleoside catabolic process
phosphate ion binding
urate metabolic process
purine-containing compound salvage
ribonucleoside catabolic process
cellular metabolic compound salvage
nucleoside catabolic process
pyridine-containing compound metabolic process
glycosyl compound catabolic process
purine nucleotide catabolic process
positive regulation of alpha-beta T cell differentiation
cytokine secretion
nucleobase-containing small molecule catabolic process
purine-containing compound catabolic process
drug binding
positive regulation of alpha-beta T cell activation
purine ribonucleoside metabolic process
regulation of alpha-beta T cell differentiation
purine nucleoside metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
ribonucleoside metabolic process
positive regulation of T cell differentiation
regulation of alpha-beta T cell activation
positive regulation of lymphocyte differentiation
positive regulation of T cell proliferation