POLR1B

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dinaciclib 0.007μM R07 exp355	-2.43
Cannabidiol 20μM R08 exp466	-2.33
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-2.32
Tanespimycin 14μM R08 exp527	-2.28
SNS-032 15μM R08 exp443	-2.24
Quinacrine 2.5μM R03 exp146	-2.11
HMS-I1 10μM R06 exp256	-2
42°C R08 exp539	-1.95
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.9
2-Deoxy-D-glucose 800μM R05 exp214	-1.88
QNZ 0.01μM R08 exp439	-1.8
ONC212 0.15μM R08 exp513	-1.78
Phenformin 20μM R03 exp143	1.74
GSK591 2.6μM R03 exp128	1.81
UM131593 0.1μM R01 exp58	1.85
Hydroxychloroquine 30μM R08 exp490	1.91
ABT-702 5μM R06 exp261	2.03
BI-2536 0.001μM R01 exp41	2.15

Global Fraction of Cell Lines Where Essential: 568/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	20/28
blood	19/28
bone	16/25
breast	22/33
central nervous system	51/56
cervix	4/4
colorectal	13/17
esophagus	12/13
fibroblast	1/1
gastric	14/15
kidney	15/21
liver	17/20
lung	60/75
lymphocyte	11/14
ovary	20/26
pancreas	17/24
peripheral nervous system	13/16
plasma cell	8/15
prostate	0/1
skin	19/24
soft tissue	5/7
thyroid	2/2
upper aerodigestive	20/22
urinary tract	26/29
uterus	5/5

Expression Distribution

Gene	Correlation
HGC6.3	0.502
RPL8	0.401

nucleologenesis
ribonucleoside binding
nucleolus organization
RNA polymerase I complex
RNA polymerase I activity
rRNA transcription
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
DNA-directed 5-3 RNA polymerase activity
transcription initiation from RNA polymerase I promoter
embryo implantation
transcription by RNA polymerase I
positive regulation of gene expression, epigenetic
DNA-templated transcription, termination
DNA-templated transcription, elongation
ncRNA transcription
nucleus organization
female pregnancy
multi-multicellular organism process
DNA-templated transcription, initiation
regulation of gene expression, epigenetic
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleolus
multi-organism reproductive process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
reproductive process
reproduction
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of gene expression
gene expression