POLR3GL

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. {ECO:0000269|PubMed:20154270}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
YM155 0.001μM R08 exp432	-2.06
Bisphenol A 100μM R06 exp269	1.72
BI-2536 0.001μM R01 exp41	1.82
Docetaxel 0.002μM R01 exp45	1.85
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.88
LB-100 4.1μM R02 exp72	1.91
2-Deoxy-D-glucose 800μM R05 exp214	2.02
Erlotinib 10μM R05 exp216	2.02
IU1-47 25μM R04 exp182	2.33

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA polymerase III complex
DNA-directed 5-3 RNA polymerase activity
transcription by RNA polymerase III
positive regulation of type I interferon production
regulation of type I interferon production
nuclear chromatin
positive regulation of cytokine production
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of cytokine production
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of multicellular organismal process
macromolecule biosynthetic process
gene expression