RERG

Entrez Summary: N/A
UniProt Summary: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. {ECO:0000269|PubMed:11533059}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11μM R07 exp409	-1.93
Cycloheximide 0.02μM R00 exp14	-1.9
UM0125461 0.74μM R02 exp84	-1.81
UNC1999 2μM R03 exp155	1.73
Oligomycin-A 2μM R00 exp25	1.76
Arsenate 40μM R06 exp264	1.8
Betulinic acid 10 to 15μM on day4 R05 exp222	1.82
Caffeine 2600μM R08 exp463	1.84
Bafilomycin-A1 0.009μM R08 exp454	1.87
SB203580 25μM R03 exp149	1.87
Bisphenol F 50μM R08 exp457	2.12

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

estrogen receptor binding
GDP binding
negative regulation of cell growth
negative regulation of growth
Ras protein signal transduction
small GTPase mediated signal transduction
GTPase activity
GTP binding
regulation of cell growth
regulation of growth
negative regulation of cell population proliferation
response to hormone
response to endogenous stimulus
regulation of cell population proliferation
intracellular signal transduction