RNF121

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trientine 500μM R08 exp534	-1.95
Atovaquone 15μM R08 exp451	-1.75
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.75
Wiskostatin 3μM R07 exp422	1.97

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ubiquitin-dependent ERAD pathway
ERAD pathway
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
cellular response to topologically incorrect protein
response to unfolded protein
response to topologically incorrect protein
ubiquitin protein ligase activity
response to endoplasmic reticulum stress
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
Golgi membrane
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
endoplasmic reticulum membrane
protein modification by small protein conjugation or removal
response to organonitrogen compound
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
proteolysis
cellular response to stress
organic substance catabolic process
cellular catabolic process