RNF165

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. {ECO:0000250|UniProtKB:E9QAU8}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-C3HC4
zf-rbx1

innervation
motor neuron axon guidance
positive regulation of BMP signaling pathway
multicellular organism aging
forelimb morphogenesis
nerve development
regulation of BMP signaling pathway
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
limb morphogenesis
appendage morphogenesis
limb development
appendage development
ubiquitin protein ligase activity
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
axon guidance
neuron projection guidance
regulation of cellular response to growth factor stimulus
aging
protein polyubiquitination
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
muscle structure development
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
protein-containing complex
neuron projection development
protein catabolic process
protein ubiquitination
cell morphogenesis
protein modification by small protein conjugation
neuron development
cellular component morphogenesis
zinc ion binding
protein modification by small protein conjugation or removal