RPL10

Entrez Summary: This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
UniProt Summary: Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788). {ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468, ECO:0000305|PubMed:12962325}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-2.02
Vinblastine 0.015μM R05 exp208	-1.83
JQ1 0.8μM R08 exp435	-1.75
IWR1 50μM R08 exp495	1.74
THZ531 0.225μM R08 exp444	1.75
Cincreasin 100μM R08 exp473	1.79
Fas-L 44ng/ml R08 exp482	1.81
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.92
UM0011500 10μM R05 exp246	1.97
BAY-598 4μM R05 exp220	2
MSC2530818 10μM R07 exp379	2.32
Resveratrol 16μM R03 exp147	2.35
Nicotinate 1000μM R03 exp140	2.62
Mubritinib 0.2μM R01 exp48	3.01

Global Fraction of Cell Lines Where Essential: 663/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	25/28
blood	26/26
bone	25/26
breast	28/30
central nervous system	47/49
cervix	4/4
colorectal	16/17
esophagus	11/11
fibroblast	1/1
gastric	14/14
kidney	17/18
liver	17/19
lung	69/72
lymphocyte	15/16
ovary	25/25
pancreas	22/22
peripheral nervous system	15/15
plasma cell	11/12
prostate	1/1
skin	20/20
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	24/28
uterus	5/5

Expression Distribution

embryonic brain development
translation regulator activity
smooth endoplasmic reticulum
ribosomal large subunit assembly
ribosome assembly
cytosolic large ribosomal subunit
ribosomal large subunit biogenesis
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
viral transcription
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
viral gene expression
protein localization to endoplasmic reticulum
translational initiation
protein targeting to membrane
structural constituent of ribosome
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA catabolic process
establishment of protein localization to membrane
ribosome biogenesis
regulation of translation
protein targeting
nucleobase-containing compound catabolic process
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
establishment of protein localization to organelle
embryonic organ development
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ribonucleoprotein complex biogenesis
protein localization to membrane
organic cyclic compound catabolic process
posttranscriptional regulation of gene expression