RPL27

Entrez Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L27e family of ribosomal proteins and a component of the 60S subunit. A splice site mutation in this gene has been identified in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017].
UniProt Summary: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CI-1040 9.5μM R08 exp472	-1.75
Nifuroxazide 1μM R01 exp51	1.73
Trichostatin-A 0.06μM R07 exp415	1.73
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.77
All-trans-Retinoic-Acid 8μM R07 exp333	1.8
NFN1 0.1μM R01 exp49	2.03
Pomalidomide 20μM R07 exp391	2.05
2-Methoxyestradiol 0.2μM R01 exp40	2.16
BI-2536 0.0042μM R03 exp95	2.64

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Ribosomal L27e
KOW

cytoplasmic side of rough endoplasmic reticulum membrane
ribosome
cytosolic large ribosomal subunit
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
viral transcription
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
viral gene expression
protein localization to endoplasmic reticulum
translational initiation
ribonucleoprotein complex
protein targeting to membrane
structural constituent of ribosome
nuclear-transcribed mRNA catabolic process
rRNA processing
mRNA catabolic process
rRNA metabolic process
RNA catabolic process
establishment of protein localization to membrane
ribosome biogenesis
protein targeting
nucleobase-containing compound catabolic process
translation
ncRNA processing
peptide biosynthetic process
focal adhesion
establishment of protein localization to organelle
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ribonucleoprotein complex biogenesis
ncRNA metabolic process
organic cyclic compound catabolic process
protein localization to membrane
amide biosynthetic process
peptide metabolic process
mRNA metabolic process
viral process