RSC1A1

Entrez Summary: N/A
UniProt Summary: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network. {ECO:0000269|PubMed:14724758, ECO:0000269|PubMed:16788146, ECO:0000269|PubMed:8836035}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.2μM R01 exp40	-2.05
Mubritinib 0.2μM R01 exp48	-2.05
Adefovir 20μM R07 exp332	-2.03
Dinaciclib 0.007μM R07 exp355	-1.93
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.78
A-196 10μM R03 exp114	1.7
PFI-3 10μM R03 exp144	1.81
S-trityl-L-cysteine 0.5μM R05 exp243	2.21

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sodium channel inhibitor activity
negative regulation of glucose transmembrane transport
negative regulation of exocytosis
regulation of glucose transmembrane transport
negative regulation of transmembrane transport
negative regulation of secretion by cell
regulation of exocytosis
negative regulation of secretion
negative regulation of transport
cell junction
regulation of vesicle-mediated transport
regulation of transmembrane transport
regulation of secretion by cell
regulation of secretion
Golgi apparatus
regulation of transport