RSF1

Entrez Summary: N/A
UniProt Summary: Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM131593 0.1μM R01 exp58	-1.8
All-trans-Retinoic-Acid 8μM R07 exp333	1.71
GSK626616 14μM R08 exp485	1.74
Trimetrexate 0.03μM R08 exp535	1.77
Tunicamycin 0.04μM R07 exp418	1.86
Zebularine 20μM R07 exp423	1.87
All-trans-Retinoic-Acid 40μM R07 exp334	1.89
QNZ 0.01μM R05 exp241	1.89
Thapsigargin 0.005μM R07 exp407	1.96
Dexamethasone 0.006μM R07 exp351	2
EPZ-5676 30μM R05 exp233	2.04
I-BRD9 4μM R07 exp365	2.1
MK-1775 0.32μM R02 exp75	2.14
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.21
Rapamycin 10μM R00 exp30	2.35
Calcium Ionophore 0.4μM R07 exp342	2.41
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.41
LB-100 2μM R05 exp210	2.57

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
HGC6.3	0.473
ZNF148	0.41

RSF complex
nucleosome positioning
histone acetyltransferase complex
CENP-A containing chromatin organization
CENP-A containing nucleosome assembly
chromatin remodeling at centromere
centromere complex assembly
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
positive regulation of viral transcription
histone exchange
histone acetyltransferase activity
negative regulation of DNA binding
regulation of viral transcription
ATP-dependent chromatin remodeling
positive regulation of viral process
histone acetylation
nucleosome assembly
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
regulation of DNA binding
histone binding
chromatin assembly
protein acetylation
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
negative regulation of binding
DNA packaging
protein acylation
protein-DNA complex assembly
regulation of viral process
DNA-templated transcription, initiation
regulation of symbiosis, encompassing mutualism through parasitism
ATPase activity
nuclear chromatin
protein-DNA complex subunit organization
DNA conformation change
peptidyl-lysine modification