SCO1

Entrez Summary: Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of MT-CO2/COX2. {ECO:0000269|PubMed:15659396, ECO:0000269|PubMed:16735468, ECO:0000269|PubMed:17189203}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

host cell mitochondrial intermembrane space
cellular copper ion homeostasis
copper ion transport
copper ion homeostasis
mitochondrial respiratory chain complex IV assembly
respiratory chain complex IV assembly
myofibril
cytochrome complex assembly
integral component of mitochondrial inner membrane
copper ion binding
negative regulation of proteasomal protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of cellular protein catabolic process
mitochondrial respiratory chain complex assembly
cellular transition metal ion homeostasis
transition metal ion transport
transition metal ion homeostasis
negative regulation of protein catabolic process
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
negative regulation of catabolic process
negative regulation of proteolysis
regulation of protein catabolic process
mitochondrial inner membrane
mitochondrion organization
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
regulation of proteolysis
cellular chemical homeostasis
ion homeostasis
cation transport
regulation of cellular catabolic process
cellular protein-containing complex assembly