SEC24C

Entrez Summary: N/A
UniProt Summary: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ML-792 0.2μM R08 exp505	-2.79
Ethanol 0.01 R05 exp234	-2.48
SNS-032 15μM R08 exp443	-1.91
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.77
Vemurafenib 6.6μM R02 exp89	2.06
UM0125461 0.74μM R02 exp84	2.17
Tubacin 1.6μM R07 exp416	2.26
Arsenate 40μM R06 exp264	2.28
BH1 1μM R04 exp169	2.35
Vemurafenib 6.6μM R08 exp434	3.25

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
HGC6.3	0.588
SEC23B	0.4

COPII-coated vesicle cargo loading
COPII vesicle coat
vesicle cargo loading
ER to Golgi transport vesicle membrane
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
SNARE binding
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
localization within membrane
vesicle targeting
vesicle budding from membrane
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
establishment of vesicle localization
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
vesicle localization
antigen processing and presentation of peptide antigen
endoplasmic reticulum to Golgi vesicle-mediated transport
antigen processing and presentation
vesicle organization
establishment of organelle localization
Golgi vesicle transport
organelle localization
Golgi membrane
zinc ion binding
membrane organization
endoplasmic reticulum membrane
intracellular protein transport
protein transport
intracellular transport
peptide transport
protein-containing complex assembly
amide transport
cellular protein localization