SESTD1

Entrez Summary: N/A
UniProt Summary: May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. {ECO:0000269|PubMed:20164195}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
1-phosphatidylinositol binding
phosphatidylinositol-5-phosphate binding
phosphatidic acid binding
calcium channel complex
phosphatidylcholine binding
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-4-phosphate binding
negative regulation of calcium ion transmembrane transport
phosphatidylinositol-3-phosphate binding
intermediate filament cytoskeleton
phosphatidylserine binding
negative regulation of calcium ion transport
phosphatidylinositol-4,5-bisphosphate binding
negative regulation of cation transmembrane transport
negative regulation of ion transmembrane transport
negative regulation of transmembrane transport
negative regulation of ion transport
regulation of calcium ion transmembrane transport
regulation of calcium ion transport
regulation of cation transmembrane transport
regulation of metal ion transport
regulation of ion transmembrane transport
negative regulation of transport
regulation of transmembrane transport
regulation of ion transport
regulation of transport