SFMBT2

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor of HOXB13 gene. {ECO:0000269|PubMed:23385818}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BN82002 4μM R07 exp340	-2.06
Trimetrexate 0.03μM R08 exp535	-1.93
Trichostatin-A 0.06μM R07 exp415	1.72
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.73
Rapamycin 2μM R07 exp306	1.76
All-trans-Retinoic-Acid 40μM R07 exp334	1.77
BI-6727 0.001μM R01 exp42	1.78
PU-H71 1μM R08 exp515	1.84
PF-06409577 20μM R07 exp389	2.01
BS-181 20μM R08 exp461	2.48

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

aggresome
histone binding
transcription corepressor activity
nuclear speck
intracellular membrane-bounded organelle
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression