SKAP1

Entrez Summary: N/A
UniProt Summary: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. {ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296, ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of cell-cell adhesion mediated by integrin
positive regulation of integrin activation
regulation of cell-cell adhesion mediated by integrin
regulation of integrin activation
positive regulation of heterotypic cell-cell adhesion
microtubule plus-end binding
microtubule plus-end
positive regulation of cell adhesion mediated by integrin
regulation of heterotypic cell-cell adhesion
plasma membrane raft
SH2 domain binding
immunological synapse
cellular response to epidermal growth factor stimulus
regulation of cell adhesion mediated by integrin
response to epidermal growth factor
positive regulation of cell-matrix adhesion
SH3/SH2 adaptor activity
protein phosphatase binding
ruffle
positive regulation of adaptive immune response
regulation of cell-matrix adhesion
positive regulation of cell-substrate adhesion
T cell receptor complex
SH3 domain binding
regulation of adaptive immune response
cell-cell junction
T cell receptor signaling pathway
protein localization to plasma membrane
regulation of cell-substrate adhesion
positive regulation of leukocyte cell-cell adhesion
protein localization to cell periphery
positive regulation of protein complex assembly
positive regulation of cell-cell adhesion
protein-containing complex binding
antigen receptor-mediated signaling pathway
regulation of leukocyte cell-cell adhesion
regulation of cell-cell adhesion
positive regulation of cell adhesion
immune response-activating cell surface receptor signaling pathway
regulation of protein complex assembly