SLC16A12

Entrez Summary: This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010].
UniProt Summary: Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane. {ECO:0000269|PubMed:23578822}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Diethyl-meta-toluamide 500μM R08 exp438	-2.03
Pterostilbene 16μM R02 exp78	-1.93
Metformin 100 to 150μM on day4 R04 exp170	-1.75
TNF-alpha 44ng/ml R08 exp533	1.88
GW501516 25μM R06 exp285	1.93
Ribavirin 10μM R01 exp52	2.01

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

creatine transmembrane transporter activity
creatine transmembrane transport
monocarboxylic acid transmembrane transporter activity
modified amino acid transport
symporter activity
drug transmembrane transport
organic acid transmembrane transport
carboxylic acid transmembrane transport
monocarboxylic acid transport
drug transport
anion transmembrane transport
carboxylic acid transport
organic acid transport
organic anion transport
anion transport
ion transmembrane transport
response to drug
transmembrane transport
ion transport
integral component of plasma membrane
nitrogen compound transport