SPC24

Entrez Summary: N/A
UniProt Summary: Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:23085020}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol A 100μM R06 exp269	-2.5
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.16
Beta-Estradiol 0.55μM R07 exp425	-1.88
BI-D1870 2μM R04 exp162	-1.81
Lapatinib 5μM R01 exp47	1.7
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.71
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.8
Trametinib 10μM R02 exp83	1.92
HMS-I2 1μM R06 exp286	2
Ethanol 0.01 R05 exp234	2.25
Phenformin 20μM R03 exp143	2.35
Dimethyloxaloylglycine 100μM R05 exp229	2.44

Global Fraction of Cell Lines Where Essential: 738/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Ndc80 complex
condensed chromosome kinetochore
cell division
nucleolus
cell cycle