SREBF2
Gene Information
- Official Symbol: SREBF2
- Official Name: sterol regulatory element binding transcription factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6721
- UniProt: Q12772
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| C-8 sterol isomerase activity |
| regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter |
| SREBP-SCAP-Insig complex |
| regulation of lipid transport by regulation of transcription from RNA polymerase II promoter |
| negative regulation of cholesterol efflux |
| cellular response to laminar fluid shear stress |
| positive regulation of cholesterol storage |
| negative regulation of sterol transport |
| negative regulation of cholesterol transport |
| response to laminar fluid shear stress |
| regulation of cholesterol storage |
| cellular response to fluid shear stress |
| cellular response to low-density lipoprotein particle stimulus |
| positive regulation of lipid storage |
| regulation of cholesterol efflux |
| negative regulation of lipid transport |
| response to lipoprotein particle |
| cellular response to lipoprotein particle stimulus |
| positive regulation of pri-miRNA transcription by RNA polymerase II |
| positive regulation of protein targeting to mitochondrion |
| response to fluid shear stress |
| negative regulation of lipid localization |
| regulation of autophagy of mitochondrion |
| regulation of pri-miRNA transcription by RNA polymerase II |
| regulation of cholesterol biosynthetic process |
| regulation of sterol biosynthetic process |
| regulation of protein targeting to mitochondrion |
| regulation of cholesterol transport |
| regulation of lipid storage |
| regulation of sterol transport |
| E-box binding |
| ER to Golgi transport vesicle membrane |
| regulation of cholesterol metabolic process |
| positive regulation of establishment of protein localization to mitochondrion |
| regulation of establishment of protein localization to mitochondrion |
| regulation of alcohol biosynthetic process |
| cholesterol homeostasis |
| sterol homeostasis |
| positive regulation of lipid localization |
| regulation of protein targeting |
| regulation of steroid biosynthetic process |
| regulation of lipid transport |
| regulation of steroid metabolic process |
| positive regulation of mitochondrion organization |
| cholesterol metabolic process |
| secondary alcohol metabolic process |
| lipid homeostasis |
| sterol metabolic process |
| regulation of lipid localization |
| cellular response to starvation |
| positive regulation of intracellular protein transport |
| protein dimerization activity |
| regulation of mitochondrion organization |
| regulation of lipid biosynthetic process |
| protein C-terminus binding |
| response to starvation |
| positive regulation of intracellular transport |
| regulation of intracellular protein transport |
| cellular response to nutrient levels |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| steroid metabolic process |
| cellular response to extracellular stimulus |
| alcohol metabolic process |
| positive regulation of cellular protein localization |
| regulation of autophagy |
| cellular response to external stimulus |
| regulation of intracellular transport |
| regulation of lipid metabolic process |
| positive regulation of protein transport |
| regulation of small molecule metabolic process |
| organic hydroxy compound metabolic process |
| positive regulation of establishment of protein localization |
| negative regulation of transport |
| response to nutrient levels |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| response to extracellular stimulus |
| regulation of cellular protein localization |
| Golgi membrane |
| positive regulation of organelle organization |
| DNA-binding transcription factor activity |
| intracellular membrane-bounded organelle |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of cellular catabolic process |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| regulation of cellular localization |
| endoplasmic reticulum membrane |
| positive regulation of transport |
| regulation of catabolic process |
| response to organonitrogen compound |
| endoplasmic reticulum |
| regulation of protein localization |
| response to nitrogen compound |
| chemical homeostasis |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| lipid metabolic process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| small molecule metabolic process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8311
- Expression level (log2 read counts): 8.82
Expression Distribution
SREBF2 Expression in NALM6 Cells: 8.82
