STAG1

Entrez Summary: N/A
UniProt Summary: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	3/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	0/5

Expression Distribution

cohesin complex
regulation of mitotic spindle assembly
mitotic spindle pole
regulation of spindle assembly
regulation of mitotic spindle organization
regulation of spindle organization
sister chromatid cohesion
chromosome, centromeric region
nuclear matrix
chromatin
chromosome
sister chromatid segregation
regulation of mitotic nuclear division
regulation of microtubule cytoskeleton organization
regulation of nuclear division
nuclear chromosome segregation
regulation of organelle assembly
regulation of microtubule-based process
chromosome segregation
nuclear body
chromatin binding
DNA-binding transcription activator activity, RNA polymerase II-specific
cell division
regulation of cytoskeleton organization
regulation of mitotic cell cycle
regulation of cell cycle process
regulation of cellular component biogenesis
cell cycle process
chromosome organization
regulation of cell cycle
positive regulation of transcription by RNA polymerase II
regulation of organelle organization
cell cycle
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process