SYNC
Gene Information
- Official Symbol: SYNC
- Official Name: syncoilin, intermediate filament protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 81493
- UniProt: Q9H7C4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
- UniProt Summary: Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. {ECO:0000250|UniProtKB:Q9EPM5}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8359
- Expression level (log2 read counts): 4.2
SYNC Expression in NALM6 Cells: 4.2
