TRMT44

Entrez Summary: The protein encoded by this gene is a putative tRNA methyltransferase found in the cytoplasm. Defects in this gene may be a cause of partial epilepsy with pericentral spikes (PEPS), but that has not been proven definitively. [provided by RefSeq, May 2012].
UniProt Summary: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aphidicolin 0.4μM R08 exp440	-2.44
PU-H71 1μM R08 exp515	-2.06
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.01
UM0131023 0.05μM R05 exp248	-1.76
Bisphenol A 100μM R06 exp269	-1.73
Nifuroxazide 1μM R01 exp51	1.7
Taxol 0.002μM R01 exp54	1.98
GSK591 2.6μM R03 exp128	2.1

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tRNA (uracil) methyltransferase activity
tRNA methylation
RNA methylation
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
macromolecule methylation
methylation
ncRNA processing
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression